The Application And Development Of Tropical Blister Packing Machine


0 Introduction

The tropical blister packing machine for medicine is also called blister eye packing, or PTP for short. Aluminum foil has a wide range of applications, especially in drug packing because of its advantages of non-toxic, high blackout, oxygen resistance and moisture resistance. With the progress of technology, in addition to the traditional tropical blister packing machine aluminum foil, aluminum foil is also combined with various plastics and paper materials as pharmaceutical packing materials, such as children's safety Blister aluminum foil, cold stamping aluminum foil, tropical blister packing aluminum foil suppository powder composite film, etc. Due to the difference of economic development level in different countries, the consumption structure of aluminum foil also has a great gap. In developed countries in Europe and America, aluminum foil products used for packing account for 70% of the total demand. In the Chinese market, the packaged aluminum foil products only account for 30% of the total domestic demand. Although the development of aluminum foil packing is relatively late, the market is growing rapidly and the prospect is attracting people's attention.

Introduction Of tropical blister packing machine

1. Performance characteristics of aluminum foil materials

Aluminum foil is generally used for moisture-proof inner packing or making composite materials and soft packing. Aluminum foil is a kind of flexible metal sheet, which is made of 0.4-0.7 mm thick industrial pure aluminum sheet after many times of cold rolling.

At present, the aluminum foil used in the pharmaceutical tropical blister packing machine is the sealing material, also known as the sealing material, commonly known as PTP medical aluminum foil. It is based on hard industrial aluminum foil, which is non-toxic, corrosion-resistant, impermeable, hygienic, heat-resistant, moisture-proof and other advantages. It is easy to carry out high-temperature disinfection and sterilization, and it can block light, which can protect the medicine from the damage of light. Before sealing the aluminum foil cover material with the plastic hard film, it is required to print the text and pattern on the printing brush coater, and apply the protective agent, while on the other side of the aluminum foil With adhesive.

The aluminum foil material is made of 99% electrolytic aluminum by postponing and other processing methods. It is nontoxic and tasteless, with high-quality conductivity and blackout as well as high moisture-proof and gas resistance. The requirement for the pinhole size of medical aluminum foil is that the pinhole diameter of 0.1-0.3 mm should not be more than 1 / m2. The pinhole in the aluminum foil is a penetrating defect. When health food and medicine are invaded by oxygen, water vapor and light, the efficacy will be reduced or deteriorated.

As the recovery of aluminum foil is very easy, and there is almost no pollution to the environment, it is a good development direction to replace plastic and paper with aluminum foil. Many food and medicine can be packaged in containers made of aluminum foil.

Aluminum is nontoxic and tasteless. It has excellent light blocking, moisture-proof, gas blocking and odor preserving properties. Theoretically, perfect aluminum foil can completely block any gas and light, and can protect the package most effectively. Almost all materials requiring light tight and high barrier are made of aluminum foil as a barrier layer, so aluminum foil has been widely used in the pharmaceutical packing industry.

At present, compared with the imported products, there is still a gap in the application of pharmaceutical aluminum foil in China, mainly in the following aspects:

(1) the number of pinholes of medical aluminum foil can not meet the use requirements. The number of pinholes in aluminum foil is a penetration defect, which seriously affects the barrier of aluminum foil, especially when it is applied to the outer packing of drugs, it is easy to make oxygen, water vapor and light penetrate and reduce the efficacy.

(2) the thickness of domestic medical aluminum foil is uneven, and its tensile strength is low. Different thickness will affect the uniformity of the coating amount of adhesive, and then affect the thermal bonding strength of aluminum foil and plastic hard disk. The low tensile strength will lead to the breaking of the foil when the tension is applied when the aluminum foil is put and rolled in the printing process, and the continuous printing operation cannot be carried out.

(3) residual oil stain on the surface of aluminum foil. Because oil is used to cool and shape aluminum foil in the process of calendering and drawing, oil stains often exist in the finished aluminum foil products. The greasy dirt on the surface will affect the adhesion between the printing ink and the protective agent and the aluminum foil material, resulting in a series of quality problems, such as unclear handwriting, peeling of the protective agent and the aluminum foil, etc.

Performance characteristics of aluminum foil materials

2 blister materials in the tropical blister packing machine

At present, most of the blister materials for drug packing are PVC and PVDC. Because drugs are sensitive to moisture, moisture and light penetration, they are often susceptible to deterioration or failure. Therefore, it is required that the plastic hard disk should have a good barrier of water, steam, light, etc. Among them, polyvinyl chloride (PVC) is not ideal in moisture resistance and gas resistance. Some manufacturers have applied polyvinylidene chloride (PVDC) or its composite materials in this field. Polyvinylidene chloride (PVDC) or its composite materials have good barrier to oxygen, water vapor and carbon dioxide in the air. Compared with the materials of the same thickness, PVDC's barrier to oxygen is 1500 times of polyethylene (PE), 100 times of polypropylene (PP), 100 times of polyester (PET), and its water vapor and air resistance are better than PVC. In addition, the sealing performance, impact strength, tensile strength, durability and other indicators of PVDC can meet the requirements of drug packing. Another trend is to gradually use such plastic composite materials as PVC / PVDC / PE, PVDC / OPP / PE to replace the plastic hard disk. Its comprehensive advantages can be reflected in one body, which greatly meets the packing requirements and performance indicators, and is the future development direction of aluminum plastic blister packing materials.

3. packing printing of tropical blister packing machine

The brief technological process of aluminum foil printing for drug packing is as follows: aluminum foil unwinding → intaglio printing → drying → coating protective layer → drying → coating adhesive layer → drying → aluminum foil rewinding. The ink for aluminum foil printing shall have good adhesion to the aluminum foil, the printed text pattern shall be firm and firm, the solvent release performance shall be fast, the heat resistance, wear resistance and luster performance shall be good and non-toxic, and the packaged medicine shall not be polluted, and the practical viscosity shall meet the speed and drying requirements of aluminum foil printing.

At present, printing ink for aluminum foil is mainly divided into two categories:

(1) polyamide ink. This kind of ink has good adhesion, dispersion, luster and wear resistance to all kinds of materials, and the solvent release is good and soft. When used in the printing of aluminum foil materials, the excellent performance of the ink can be shown, and its heat resistance can also meet the requirements of aluminum foil printing.

(2) the special ink for aluminum foil, which is mainly composed of vinyl chloride vinyl acetate copolymer resin / acrylic resin, is characterized by bright color, high concentration, strong adhesion with aluminum foil, and good transparency. However, when it is used for gravure printing, its solvent volatility is large, and it is easy to cause ink drying and deposition in the ink hole of gravure roller during surface printing, resulting in paste phenomenon.

In the whole production process, the surface quality of letterpress pattern and the heat sealing strength of the adhesive layer, the adhesion and drying temperature of the protective layer, and the speed and tension control of the coating machine operation need to be strictly controlled in the process operation. Therefore, in the national standard of aluminum foil for drug packing, there are clear requirements for the surface quality of printed characters of medical aluminum foil, as well as physical and chemical indexes for the performance of protective layer and adhesive layer, so as to protect medical PTP aluminum foil with better separation, health and safety, heat sealing and good physical and mechanical properties. In order to achieve the above-mentioned properties in the process of PTP aluminum foil printing and coating, the following problems should be paid attention to during the operation:

A. the raw material of PTP aluminum foil is pure aluminum foil for industrial use. Generally, the thickness is 0.02 mm, the tensile strength is 98 kPa, the breaking strength is 90 kPa, the surface is clean, flat, wrinkle free, indentation free, fluorescent material free, and the surface wetting tension is not less than 32 dyn / cm. In addition, if the thickness of aluminum foil outside the packing material and equipment exceeds the required deviation (10%).

The coating amount of adhesive layer and protective layer is affected, which should be paid attention to by the operator.

B. necessary pretreatment shall be carried out for the deposition and freezing of ink, and the ink shall be stirred or the temperature shall be increased. If the storage time of the ink is too long, the ink will deposit, resulting in more resin solution on the upper layer of the ink, more pigments on the lower layer, light color on the upper layer and dark color on the lower layer, which should also be stirred evenly before use.

C. The amount of solvent added to the ink shall be appropriate. It is better to use the ink concentration detector to determine the amount of added solvent, and according to the change of temperature and humidity, measure the ink concentration every certain time. When using gravure printing to print aluminum foil products, the ink concentration is too low, which will cause the printing text pattern color is not bright, and the screen pattern will produce the paste phenomenon; when the ink concentration is too high, the pattern will produce the crack phenomenon, which not only wastes the ink, but also easily causes the printing surface to be uneven and unsightly.

D. according to the speed of the aluminum foil printing coater and the depth of the inking hole of the printing intaglio roller, the best ink is developed. The adhesive that meets the requirements of PTP aluminum foil is coated on the inner side of the aluminum foil. Its function is to make the aluminum foil and the medical PVC hard sheet firmly press together, to separate the medicine in the plastic hard sheet Blister from the outside, and to achieve the purpose of sealing the medicine. During the heat sealing process of drug loading, the adhesive layer is activated by hot pressing, so that it can be firmly bonded with PVC plastic sheet. This requires that the adhesive layer and PVC resin should have good heat sensitivity and solubility with the base material. Master the drying temperature and time for printing coating.

The printed image, adhesive layer and protective layer need to be dried in the coating process, and the drying of the aluminum foil surface coating needs to have a process, so it needs to stay in the drying path of the equipment for a certain time, which depends on the speed of winding up of the coating machine and the temperature selected in the drying path, and the two should maintain a corresponding relationship.

E. due to the different thickness of aluminum foil material, its physical and mechanical properties are different, and the thermal expansion, contraction and elongation of the material when it is running in the equipment are also different, so it should not stay too long at a very high temperature, otherwise the aluminum foil is prone to wrinkle and surface discoloration. Generally, the temperature of drying channel should be controlled at 170-210 ℃.

F. the coating speed, coating tension and coating thickness have a great influence on the bonding firmness of the PVC rigid sheet. If the bonding layer is too thin, the bonding firmness will be reduced due to the lack of materials when hot pressing the PVC rigid sheet; if the bonding layer is too thick, not only the cost will be increased, but also the drying time will be longer, so the adhesive coating needs to be controlled within the appropriate thickness range.

4. Application and development of pharmaceutical tropical blister packing machine

Aluminum foil packing began in the early 20th century, when as the most expensive packing materials, aluminum foil was only used for high-grade packing. In 1938, American heat sealing aluminum foil paper came out. In the 1950s, aluminum paper and aluminum plastic composite materials began to develop. In the 1970s, with the maturity of color printing technology, aluminum foil and aluminum plastic composite packing entered a period of rapid popularization. Since the 1990s, China's aluminum foil production has entered an important period, not only the introduction of a large number of advanced equipment, production management and technology development level has gradually moved towards modernization and internationalization. Since the 21st century, driven by the strong market demand, aluminum foil production capacity has increased rapidly. In the 21st century, the market competition and the trend of product homogeneity stimulate the rapid development of product packing. The development of aluminum foil packing basically keeps pace with the development of the whole industry, and the development of aluminum foil packing is faster in the Chinese market. There are two main reasons: (1) the gap between the development of China's soft packing market and that of developed countries is obvious, and the proportion of soft packing of daily consumer goods and food is small. Developed countries have accounted for more than 65%, some of which have exceeded 70%, while China has accounted for about 15%, and the proportion has increased rapidly in the past two years; (2) China The technology of inner aluminum-plastic composite and aluminum paper composite is becoming more and more mature, and the production cost is reduced, which promotes the popularization and application of aluminum matrix composite in China's packing market.

Aluminum foil is mainly used for blister packing in pharmaceutical packing. The tropical blister packing machine is mainly made of PVC sheet and 0.02 mm thick aluminum foil. Blister packing has become the most important packing method of Western medicine tablets and capsules. The packing of traditional Chinese medicine tablet, powder, capsule, and pellet in China is gradually changing from paper bag, simple plastic bag and glass bottle to the aluminum plastic blister pack. Blister packing has the advantages of moisture-proof, easy to carry, safety and health. With the development of drug release technology, the market will be broader. The aluminum foil market is the production of aluminum plastic easy tear film (SP). At present, there are more than 1000 such production lines for drug packing materials and equipment in China, and the demand for aluminum foil is 3000 t / A.

Blister packing is the main packing form of health food and drug solid dosage forms in China. Among them, the medical aluminum foil is based on the industrial pure aluminum foil, which is printed with text patterns on the surface and coated with protective agent, and coated with adhesive on the other side. The purpose of coating the protective agent is to prevent the abrasion of the surface printing ink layer and the contamination of the medicine caused by the contact between the outer ink and the inner adhesive when the aluminum foil is made and rolled up. The function of the adhesive is to bond the aluminum foil and the plastic hard disk, so that the medicine can be sealed. At present, the adhesives are mainly composed of one-component adhesive and two-component adhesive. The components of one component adhesive are mainly natural rubber and nitrocellulose fiber and acrylic ester charge. Because the main agent is elastomer, and the adhesive is used as auxiliary agent, the emulsion is made of organic solvent. It has non drying, hot melting and certain adhesive strength. With the improvement of hygienic requirements for pharmaceutical packing materials, the application of this single component adhesive is gradually reduced, and more two-component polyurethane adhesive is used, which is mainly composed of main agent and curing agent. The main agent generally contains many active hydrogen, such as hydroxyl, amino and other substances, while the curing agent is composed of polyisocyanate compounds. When the isocyanate group in the curing agent contacts with the active hydrogen in the main agent molecule, the addition reaction will be carried out automatically to form the structure of carbamate. The molecular weight of the main agent combined with the curing agent increases exponentially, and the cross-linking product with branched chain structure is formed from the base to the base, which has the characteristics of good resistance to high and low temperature, medium erosion and high adhesion. Because polyurethane molecules contain a large number of polar groups, large dipole moment, and have a great affinity for the materials to be adhered, so it plays a bonding role in a variety of printing materials, such as aluminum foil, plastic, etc. Due to the good adhesion of this kind of adhesive, it has been widely used in the printing, coating and bonding of aluminum foil as well as the printing and compounding of this kind of plastic film. The adhesive for aluminum foil printing is developing towards solvent-free type. Its composition is also a two-component polyurethane type. The difference is that the viscosity of the main agent and curing agent is high at room temperature, but it still has fluidity, which belongs to semi curing agent. It is mixed in proportion to a concave roller with heating and heat preservation function, and coated on the aluminum foil base material. After coating, it does not need to be heated and dried through the drying path, because there is no solution Agent, directly with another substrate for bonding. There is no problem of exhaust gas emission when using solvent-free adhesive. It is not necessary to equip a large drying channel heating drying and air blowing exhaust device in the printing coating equipment. Due to the high attention paid to environmental protection in foreign countries, this adhesive has been used.

However, aluminum foil also faces competition with other materials, mainly from nylon, EVOH, pen and other high barrier composite plastic films. The latter has transparency, making packing more attractive. While the medical aluminum foil is subject to the competition of hard PVC film coated with PVDC, the latter has advantages in cost. Of course, the biggest competition comes from the development of aluminizing technology. As vacuum aluminizing products can be based on paper or plastic and other materials, it has a wide range of applications and low cost, so it has occupied the application market of aluminum foil in many middle and low-end markets. Vacuum aluminized paper has metallic luster and is easy to print, which can meet the requirements of beauty and fashion; vacuum aluminized paper is easy to carry out laser holographic processing, which has a good anti-counterfeiting effect. Therefore, vacuum aluminized packing materials have gradually replaced aluminum foil composite paper as the main aluminum paper substrate in many occasions. With the improvement of technology, the application of aluminum foil will be further expanded.

5 Conclusion

In a word, the pharmaceutical tropical blister packing machine is a very special commodity packing which belongs to the field of packing. It should not only have all kinds of excellent properties of packing but also have the function of maintaining the curative effect of drugs. As the packing of drugs, the aluminum plastic blister has the advantages of beauty, light weight, air resistance, light resistance, etc., which makes it become the star in the packing materials of drugs. As a manufacturer of pharmaceutical PTP packing materials, the selection of high-quality thick materials before printing is a prerequisite for the production of products satisfying users. The quality of printing materials such as aluminum foil and ink is related to the quality of products. In order to avoid quality problems before printing.

We must test and control the raw materials. With the improvement of people's awareness of health care, the pharmaceutical tropical blister packing machine has been deeply into our lives, and plays an important role in packing for human health.



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